American hopes were already hit hard as both Venus Williams and Serena Williams withdrew
from the French Open earlier this month due to lingering injuries. Venus Williams had not fully recovered
from a hip injury and Serena Williams a foot injury.
Roddick lost in the opening round at both Madrid and Rome, but reached the doubles final at Rome with his fellow American Mardy Fish before withdrawing from the final with a shoulder injury.
The 28 year old had been scheduled to play at Nice Wednesday but withdrew Tuesday.
"I was already injured last week in Rome and I had to withdraw from the men's doubles final," said Roddick, whose best result at the French Open was a fourth round performance in 2009.
"I don't know yet if I will be able to play at Roland Garros and I think that you can't play a Grand Slam if you're not 100 percent," added Roddick.
The 11th ranked Roddick said that he did not want to risk playing and making the injury worse on the eve of Wimbledon.
"It is painful more when I am hitting backhands and forehands than when I am serving, and there is little bit of tendinitis," said Roddick.
"I want to avoid spending months out injured. It has not been a very good year so far."
The 10th ranked Fish earlier this month overtook Roddick as the top ranked ATP Tour player.
In 2004, Roddick delivered the fastest serve ever in tennis history at 155 miles per hour.
One year earlier, Roddick took his lone grand slam title at the US Open in 2003.