And after entering the championship match as the favorite to win, Djokovic wasted little time before asserting himself from the baseline.
Serving to stay in the first set at 4-5, 15-30, Murray netted a crosscourt forehand passing shot to end a gripping 39 shot rally. A Djokovic crosscourt backhand winner on the next following point would end the set.
In the second set, Djokovic raced to a 5-0 lead before a spirited rally from Murray would briefly prolong the set.
After winning two games to pull to 2-5, Murray netted a slice forehand on set point to fall behind by two sets.
In the final set, Djokovic broke serve at 3 all before winning the final two games of the match.
Murray, who appeared out of sorts many times throughout the encounter, would net yet another forehand to end the match.
For the 23 year old Murray, the result was particularly bitter as it marked his third grand slam finalist finish and left him still in a wait for his first grand slam singles title.
But for Djokovic, it was a deja vu as the Serb also won his only other singles grand slam title in 2008 at Melbourne.
At the 2008 Olympic Games at Beijing, China, Djokovic took the singles bronze medal.